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BMC Geriatr. 2015 Jun 4;15:62. doi: 10.1186/s12877-015-0063-7.

Elevated circulating vascular cell Adhesion Molecule-1 (sVCAM-1) is associated with concurrent depressive symptoms and cerebral white matter Hyperintensities in older adults.

Author information

1
Institute for Aging Research, Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. achilletchalla@hsl.harvard.edu.
2
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. achilletchalla@hsl.harvard.edu.
3
Harvard Medical School, Boston, Massachusetts, USA. achilletchalla@hsl.harvard.edu.
4
Geriatric Medicine Department, IFR 145 GEIST; EA 6310 HAVAE (Disability, Activity, Aging, Autonomy and Environment), Limoges University, CHU Limoges, Limoges, F-87025, France. achilletchalla@hsl.harvard.edu.
5
Brown University School of Public Health, Providence, Massachusetts, USA. gregory_wellenius@brown.edu.
6
Department of Neurology, Stroke Division, Brigham and Women's Hospital, 45 Francis St, Boston, MA, 02115, USA. fsorond@partners.org.
7
Institute for Aging Research, Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. tgt@hsl.harvard.edu.
8
Geriatric Medicine Department, IFR 145 GEIST; EA 6310 HAVAE (Disability, Activity, Aging, Autonomy and Environment), Limoges University, CHU Limoges, Limoges, F-87025, France. thierry.dantoine@chu-limoges.fr.
9
Institute for Aging Research, Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. llipsitz@bidmc.harvard.edu.
10
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. llipsitz@bidmc.harvard.edu.
11
Harvard Medical School, Boston, Massachusetts, USA. llipsitz@bidmc.harvard.edu.

Abstract

BACKGROUND:

Circulating vascular adhesion molecule-1 (sVCAM-1) is a presumed marker of endothelial activation and dysfunction, but little is known about its association with mood. We hypothesized that elevated plasma concentrations of sVCAM-1 may be a marker of depressive symptoms due to cerebral vascular disease.

METHODS:

We studied 680 community-dwelling participants in the MOBILIZE Boston Study, aged 65 years and older. sICAM-1 and sVCAM-1 were measured by ELISA assay and depressive symptoms were assessed during home interviews using the Revised Center for Epidemiological Studies Depression Scale (CESD-R). Cerebral White Matter Hyperintensities (WMHs) were quantified by MRI in a subgroup of 25 participants.

RESULTS:

One hundred seventy nine (27 %) subjects had a CESD-R Score ≥ 16, indicative of depressive symptoms. The mean sVCAM-1 concentration (±SD) was 1176 ± 417 ng/mL in a group with CESD-R Scores <16 and 1239 ± 451 ng/mL in those with CESD-R Scores ≥16 (p = 0.036). CESD-R Score was positively associated with sVCAM-1 (r = 0.11, p = 0.004). The highest quintile of sVCAM-1, which is indicative of endothelial dysfunction, was significantly associated with depressive symptoms compared to the lowest quintile (OR = 1.97 (1.14-3.57) p = 0.015). In a subset of subjects, sVCAM-1 concentration was positively correlated with cerebral WMHs volume (p = 0.018).

CONCLUSIONS:

The association between high levels of sVCAM-1 and depressive symptoms may be due to endothelial dysfunction from cerebral microvascular damage. Future longitudinal studies are needed to determine whether sVCAM-1 can serve as a biomarker for cerebrovascular causes of depression.

PMID:
26040277
PMCID:
PMC4453284
DOI:
10.1186/s12877-015-0063-7
[Indexed for MEDLINE]
Free PMC Article

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