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PLoS One. 2015 Jun 3;10(6):e0126284. doi: 10.1371/journal.pone.0126284. eCollection 2015.

Disruption of parenting behaviors in california mice, a monogamous rodent species, by endocrine disrupting chemicals.

Author information

1
Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, United States of America; Biomedical Sciences, University of Missouri, Columbia, MO, 65211, United States of America.
2
Agriculture Experimental Station-Statistics, University of Missouri, Columbia, MO, 65211, United States of America.
3
Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, United States of America; Animal Sciences, University of Missouri, Columbia, MO, 65211, United States of America; Biochemistry, University of Missouri, Columbia, MO, 65211, United States of America; Genetics Area Program, University of Missouri, Columbia, MO, 65211, United States of America.
4
Bond Life Sciences Center, University of Missouri, Columbia, MO, 65211, United States of America; Biomedical Sciences, University of Missouri, Columbia, MO, 65211, United States of America; Genetics Area Program, University of Missouri, Columbia, MO, 65211, United States of America.

Abstract

The nature and extent of care received by an infant can affect social, emotional and cognitive development, features that endure into adulthood. Here we employed the monogamous, California mouse (Peromyscus californicus), a species, like the human, where both parents invest in offspring care, to determine whether early exposure to endocrine disrupting chemicals (EDC: bisphenol A, BPA; ethinyl estradiol, EE) of one or both parents altered their behaviors towards their pups. Females exposed to either compound spent less time nursing, grooming and being associated with their pups than controls, although there was little consequence on their weight gain. Care of pups by males was less affected by exposure to BPA and EE, but control, non-exposed females appeared able to "sense" a male partner previously exposed to either compound and, as a consequence, reduced their own parental investment in offspring from such pairings. The data emphasize the potential vulnerability of pups born to parents that had been exposed during their own early development to EDC, and that effects on the male, although subtle, also have consequences on overall parental care due to lack of full acceptance of the male by the female partner.

PMID:
26039462
PMCID:
PMC4454565
DOI:
10.1371/journal.pone.0126284
[Indexed for MEDLINE]
Free PMC Article

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