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Cancers (Basel). 2015 May 22;7(2):849-75. doi: 10.3390/cancers7020813.

Voltage-gated ion channels in cancer cell proliferation.

Author information

1
Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago 2160 S. 1s tAve, Maywood, IL 60153, USA. vrao2@luc.edu.
2
Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago 2160 S. 1s tAve, Maywood, IL 60153, USA. mperezneut@luc.edu.
3
Department of Ophthalmology and Vision Research Center, School of Medicine, University of Missouri-Kansas City, 2411 Holmes St., Kansas City, MO 64108, USA. kajas@umkc.edu.
4
Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago 2160 S. 1s tAve, Maywood, IL 60153, USA. sagentile@luc.edu.

Abstract

Changes of the electrical charges across the surface cell membrane are absolutely necessary to maintain cellular homeostasis in physiological as well as in pathological conditions. The opening of ion channels alter the charge distribution across the surface membrane as they allow the diffusion of ions such as K+, Ca++, Cl.

KEYWORDS:

cancer; cell proliferation; membrane potential; voltage gated ion channel

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