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J Biol Chem. 2015 Jul 10;290(28):17145-53. doi: 10.1074/jbc.R115.640359. Epub 2015 May 8.

Intermediate Filaments Play a Pivotal Role in Regulating Cell Architecture and Function.

Author information

1
From the Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 and.
2
the Division of Molecular Genetics (B060), German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany.
3
From the Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611 and r-goldman@northwestern.edu.

Abstract

Intermediate filaments (IFs) are composed of one or more members of a large family of cytoskeletal proteins, whose expression is cell- and tissue type-specific. Their importance in regulating the physiological properties of cells is becoming widely recognized in functions ranging from cell motility to signal transduction. IF proteins assemble into nanoscale biopolymers with unique strain-hardening properties that are related to their roles in regulating the mechanical integrity of cells. Furthermore, mutations in the genes encoding IF proteins cause a wide range of human diseases. Due to the number of different types of IF proteins, we have limited this short review to cover structure and function topics mainly related to the simpler homopolymeric IF networks composed of vimentin, and specifically for diseases, the related muscle-specific desmin IF networks.

KEYWORDS:

cell motility; cytoskeleton; intermediate filament; mechanotransduction; signal transduction

PMID:
25957409
PMCID:
PMC4498054
DOI:
10.1074/jbc.R115.640359
[Indexed for MEDLINE]
Free PMC Article

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