J Clin Microbiol. 2015 Mar;53(3):1031-3. doi: 10.1128/JCM.03623-14. Epub 2014 Dec 31.

Four carbapenem-resistant gram-negative species carrying distinct carbapenemases in a single patient.

Ding B¹, Hu F¹, Yang Y¹, Guo Q¹, Huang J¹, Wang M².

Author information

1: Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China.
2: Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China mgwang@fudan.edu.cn.

Abstract

Carbapenem-resistant Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Acinetobacter baumannii were isolated from a single patient, each producing different carbapenemases (NDM-1, KPC-2, IMP, and OXA-23, respectively). The NDM-1-producing E. coli strain was preceded by a clonally related carbapenem-susceptible strain a month earlier, suggesting in vivo acquisition of blaNDM-1.