Format

Send to

Choose Destination
Nat Immunol. 2014 Oct;15(10):973-81. doi: 10.1038/ni.2965. Epub 2014 Aug 24.

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells.

Author information

1
1] Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA. [2].
2
1] Program in Cellular and Molecular Medicine, Children's Hospital, Boston, Massachusetts, USA. [2] Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA. [3].
3
Institute of Immunobiology, Kantonal Hospital St. Gallen, St. Gallen, Switzerland.
4
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
5
1] Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA. [2] Division of Medical Sciences, Harvard Medical School, Boston, Massachusetts, USA.
6
1] Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA. [2] Department of Pharmacology, University of Milan, Milan, Italy.
7
1] Program in Cellular and Molecular Medicine, Children's Hospital, Boston, Massachusetts, USA. [2] Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
8
1] Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA. [2] Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA. [3].

Abstract

Fibroblastic reticular cells (FRCs) are known to inhabit T cell-rich areas of lymphoid organs, where they function to facilitate interactions between T cells and dendritic cells. However, in vivo manipulation of FRCs has been limited by a dearth of genetic tools that target this lineage. Here, using a mouse model to conditionally ablate FRCs, we demonstrated their indispensable role in antiviral T cell responses. Unexpectedly, loss of FRCs also attenuated humoral immunity due to impaired B cell viability and follicular organization. Follicle-resident FRCs established a favorable niche for B lymphocytes via production of the cytokine BAFF. Thus, our study indicates that adaptive immunity requires an intact FRC network and identifies a subset of FRCs that control B cell homeostasis and follicle identity.

PMID:
25151489
PMCID:
PMC4205585
DOI:
10.1038/ni.2965
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center