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Pediatr Obes. 2015 Apr;10(2):77-83. doi: 10.1111/ijpo.230. Epub 2014 Jun 11.

A high birth weight is associated with increased risk of type 2 diabetes and obesity.

Author information

1
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Abstract

BACKGROUND:

The association between low birth weight and adult disease is well known. Less is known on long-term effects of high birth weight.

OBJECTIVE:

This study aims to investigate whether a high birth weight increases risk for adult metabolic disease.

METHODS:

Swedish term single births, 1973-1982 (n = 759,999), were studied to age 27.5-37.5 years using Swedish national registers. Hazard ratios (HRs) were calculated in relation to birth weight for type 2 diabetes, obesity, hypertension and dyslipidaemia.

RESULTS:

Men with birth weights between 2 and 3 standard deviation score (SDS) had a 1.9-fold increased risk (HR 1.91, 95% confidence interval [CI] 1.25-2.90) of type 2 diabetes, whereas those with birth weights above 3 SDS had a 5.4-fold increased risk (HR 5.44, 95% CI 2.70-10.96) compared to men with birth weights between -2 and 2 SDS. The corresponding HRs for women were 0.60 (95% CI 0.40-0.91) and 1.71 (95% CI 0.85-3.43) for birth weights 2-3 SDS and >3 SDS, respectively. Men with birth weights between 2 and 3 SDS had a 1.5-fold increased risk (HR 1.47, 95% CI 1.22-1.77) of obesity. The corresponding risk for women was 1.3-fold increased (HR 1.32, 95% CI 1.19-1.46). For men and women with birth weights above 3 SDS, the risks of adult obesity were higher, HR 2.46 (95% CI 1.63-3.71) and HR 1.85 (95% CI 1.44-2.37), respectively.

CONCLUSIONS:

A high birth weight, particularly very high, increases the risk of type 2 diabetes in male young adults. The risk of obesity increases with increasing birth weight in both genders.

KEYWORDS:

High birth weight; large for gestational age (LGA); obesity; type 2 diabetes

PMID:
24916852
DOI:
10.1111/ijpo.230
[Indexed for MEDLINE]

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