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Expert Rev Vaccines. 2014 Jul;13(7):909-25. doi: 10.1586/14760584.2014.920236. Epub 2014 May 23.

Toll-like receptor-based adjuvants: enhancing the immune response to vaccines against infectious diseases of chicken.

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Division of Veterinary Biotechnology, Recombinant DNA Lab, Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, UP, India.


Huge productivity loss due to infectious diseases in chickens is a major problem and, hence, robust development of the poultry industry requires control of poultry health. Immunization using vaccines is routine practice; however, to combat infectious diseases, conventional vaccines as well as new-generation recombinant vaccines alone, due to relatively weak immunogenicity, may not be effective enough to provide optimum immunity. With this in mind, there is a need to incorporate better and more suitable adjuvants in the vaccines to elicit the elevated immune response in the host. Over last few decades, with the increase in the knowledge of innate immune functioning, efforts have been made to enhance vaccine potency using novel adjuvants like Toll-like receptor based adjuvant systems. In this review, we will discuss the potential use of toll-like receptor ligands as an adjuvant in vaccines against the infectious diseases of chickens.


TLR; adjuvants; agonist; chicken; cytokine; infectious disease; poultry; vaccine

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