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PLoS One. 2014 Apr 22;9(4):e95516. doi: 10.1371/journal.pone.0095516. eCollection 2014.

Multi-parametric spinal cord MRI as potential progression marker in amyotrophic lateral sclerosis.

Author information

1
Sorbonne Universités, UPMC Univ Paris 06, UM CR 2, Laboratoire d'Imagerie Biomédicale, Paris, Île-de-France, France; CNRS, UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, Île-de-France, France; INSERM, U 1146, Laboratoire d'Imagerie Biomédicale, Paris, Île-de-France, France.
2
Ecole Polytechnique de Montréal, Département de Génie Électrique, Montréal, Québec, Canada.
3
Université de Montréal, GRSNC, Faculty de Médecine, Montréal, Québec, Canada.
4
AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Département d'Explorations Fonctionnelles Neurologiques, Paris, Île-de-France, France.
5
Inserm U975, UPMC Univ Paris 6, UMR-S975, CNRS UMR7225, Centre de recherche de l'Institut du Cerveau et de la Moelle épinière - CRICM, Centre de Neuroimagerie de Recherche - CENIR, Paris, Île-de-France, France; APHP, Groupe Hospitalier Pitié-Salpêtrière, Service de Neuroradiologie, Paris, Île-de-France, France.
6
Sorbonne Universités, UPMC Univ Paris 06, UM CR 2, Laboratoire d'Imagerie Biomédicale, Paris, Île-de-France, France; CNRS, UMR 7371, Laboratoire d'Imagerie Biomédicale, Paris, Île-de-France, France; INSERM, U 1146, Laboratoire d'Imagerie Biomédicale, Paris, Île-de-France, France; APHP, Groupe Hospitalier Pitié-Salpêtrière, Département des Maladies du système Nerveux, Paris, Île-de-France, France.

Abstract

OBJECTIVE:

To evaluate multimodal MRI of the spinal cord in predicting disease progression and one-year clinical status in amyotrophic lateral sclerosis (ALS) patients.

MATERIALS AND METHODS:

After a first MRI (MRI1), 29 ALS patients were clinically followed during 12 months; 14/29 patients underwent a second MRI (MRI2) at 11±3 months. Cross-sectional area (CSA) that has been shown to be a marker of lower motor neuron degeneration was measured in cervical and upper thoracic spinal cord from T2-weighted images. Fractional anisotropy (FA), axial/radial/mean diffusivities (λ⊥, λ//, MD) and magnetization transfer ratio (MTR) were measured within the lateral corticospinal tract in the cervical region. Imaging metrics were compared with clinical scales: Revised ALS Functional Rating Scale (ALSFRS-R) and manual muscle testing (MMT) score.

RESULTS:

At MRI1, CSA correlated significantly (P<0.05) with MMT and arm ALSFRS-R scores. FA correlated significantly with leg ALFSRS-R scores. One year after MRI1, CSA predicted (P<0.01) arm ALSFSR-R subscore and FA predicted (P<0.01) leg ALSFRS-R subscore. From MRI1 to MRI2, significant changes (P<0.01) were detected for CSA and MTR. CSA rate of change (i.e. atrophy) highly correlated (P<0.01) with arm ALSFRS-R and arm MMT subscores rate of change.

CONCLUSION:

Atrophy and DTI metrics predicted ALS disease progression. Cord atrophy was a better biomarker of disease progression than diffusion and MTR. Our study suggests that multimodal MRI could provide surrogate markers of ALS that may help monitoring the effect of disease-modifying drugs.

PMID:
24755826
PMCID:
PMC3995720
DOI:
10.1371/journal.pone.0095516
[Indexed for MEDLINE]
Free PMC Article

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