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Health Psychol Behav Med. 2014 Jan 1;2(1):41-51.

Predictors of Post-Infectious Chronic Fatigue Syndrome in Adolescents.

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DePaul University; Center for Community Research, 990 W. Fullerton Ave, Chicago, Il. 60614, (773-325-2018)( ).
Division of Infectious Diseases & Department of Pediatrics, Northwestern University & Anne, and Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Ave, Chicago, Il. 60611, (312-227-4671)( ).
715 Lake St., Suite 807,Oak Park, Illinois 60301, (708- 277-9959).
Heartland Health Centers, 3048 N Wilton, Chicago, Il. 60657, (773-296-7589) ( ).
DePaul University; Center for Community Research, 990 W. Fullerton Ave, Chicago, Il. 60614, (773-325-4900)( ).
Department of Occupational Therapy, University of Illinois at Chicago, 1919 W. Taylor St., (MC 811)Chicago, IL 60612 (312-996-3412) ( ).


This study focused on identifying risk factors for adolescent post-infectious chronic fatigue syndrome (CFS), utilizing a prospective, nested case-control longitudinal design in which over 300 teenagers with Infectious Mononucleosis (IM) were identified through primary care sites and followed. Baseline variables that were gathered several months following IM, included autonomic symptoms, days in bed since IM, perceived stress, stressful life events, family stress, difficulty functioning and attending school, family stress and psychiatric disorders. A number of variables were predictors of post-infectious CFS at 6 months; however, when autonomic symptoms were used as a control variable, only days spent in bed since mono was a significant predictor. Step-wise logistic regression findings indicated that baseline autonomic symptoms as well as days spent in bed since mono, which reflect the severity of illness, were the only significant predictors of those who met CFS criteria at 6 months.


autonomic symptoms; chronic fatigue syndrome; longitudinal; mononucleosis; risk factors

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