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Curr Opin Immunol. 2014 Jun;28:58-63. doi: 10.1016/j.coi.2014.02.003. Epub 2014 Mar 6.

Novel vaccine approaches for protection against intracellular pathogens.

Author information

1
Department of Molecular Microbiology, Campus Box 8230, 660 South Euclid Avenue, St. Louis, MO 63110-1093, USA.
2
Department of Molecular Microbiology, Campus Box 8230, 660 South Euclid Avenue, St. Louis, MO 63110-1093, USA. Electronic address: khader@wustl.edu.

Abstract

Vaccination against intracellular pathogens requires generation of a pool of memory T cells able to respond upon infection and mediate either killing of the infected cell or induce killing mechanisms in the infected cell. T cell-inducing vaccines must aim to target the antigen to antigen-presenting cells (APCs) so that it can be presented on MHC molecules on the cell surface. Methods to do this include making use of vectors such as plasmid DNA or viruses, live attenuated pathogens or subunit vaccines targeted and enhanced using adjuvants. The choice of approach should be guided by the phenotype and localization of the desired T cell response. This review will discuss current approaches in the pipeline for the development of T cell-inducing vaccines, including vectored, live attenuated, and subunit vaccines.

PMID:
24608070
PMCID:
PMC4037333
DOI:
10.1016/j.coi.2014.02.003
[Indexed for MEDLINE]
Free PMC Article

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