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Trends Biochem Sci. 2014 Jan;39(1):35-43. doi: 10.1016/j.tibs.2013.10.002. Epub 2013 Nov 27.

Long noncoding RNAs: fresh perspectives into the RNA world.

Author information

1
Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.
2
Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02114, USA. Electronic address: lee@molbio.mgh.harvard.edu.

Abstract

Large-scale mapping of transcriptomes has revealed significant levels of transcriptional activity within both unannotated and annotated regions of the genome. Interestingly, many of the novel transcripts demonstrate tissue-specific expression and some level of sequence conservation across species, but most have low protein-coding potential. Here, we describe progress in identifying and characterizing long noncoding RNAs (lncRNAs) and review how these transcripts interact with other biological molecules to regulate diverse cellular processes. We also preview emerging techniques that will help advance the discovery and characterization of novel transcripts. Finally, we discuss the role of lncRNAs in disease and therapeutics.

KEYWORDS:

Long noncoding RNA; epigenetics; next-generation sequencing; therapeutics

PMID:
24290031
PMCID:
PMC3904784
DOI:
10.1016/j.tibs.2013.10.002
[Indexed for MEDLINE]
Free PMC Article

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