Format

Send to

Choose Destination
Clin Dermatol. 2013 Jul-Aug;31(4):352-361. doi: 10.1016/j.clindermatol.2013.01.002.

Behçet's syndrome: facts and controversies.

Author information

1
Department of Dermatology, Cerrahpasa Medical Faculty, Istanbul University, 34098 Istanbul, Turkey.
2
Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical Faculty, Istanbul University, 34098 Istanbul, Turkey.
3
Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, 34098 Istanbul, Turkey.
4
Department of Dermatology, Cerrahpasa Medical Faculty, Istanbul University, 34098 Istanbul, Turkey. Electronic address: yalcintuzun@gmail.com.

Abstract

Behçet's syndrome is a systemic vasculitis of small and large vessels affecting both veins and arteries. Almost all patients with Behçet's syndrome have recurrent oral aphthae, followed by genital ulcers, variable skin lesions, such as erythema nodosum and papulopustuler lesions, arthritis, uveitis, thrombophlebitis, and gastrointestinal and central nervous system involvement. Recent epidemiologic works suggest that genetic factors are more important than environmental factors in its pathogenesis. European League Against Rheumatism guidelines were recently published for the treatment of Behçet's syndrome. Although these are quite useful for the management of mucocutaneous, eye, and joint involvement, treatment of vascular, neurological, and gastrointestinal involvement are still problematic as there are no controlled studies for these manifestations. This contribution addresses the epidemiology, mucocutaneous manifestations, diagnostic criteria, and evidence-based therapies, including biologic agents.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center