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J Pediatr. 2013 Sep;163(3):905-7. doi: 10.1016/j.jpeds.2013.04.010. Epub 2013 May 16.

Cord blood endothelial colony-forming cells from newborns with congenital diaphragmatic hernia.

Author information

1
Pediatric Heart Lung Center, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA. Christopher.Baker@UCDenver.edu

Abstract

Endothelial colony-forming cells (ECFCs) are decreased in the cord blood of preterm infants with moderate-to-severe bronchopulmonary dysplasia. We quantified ECFCs from infants with congenital diaphragmatic hernia, a neonatal disorder with severe lung hypoplasia. Unlike newborns who develop bronchopulmonary dysplasia, those with congenital diaphragmatic hernia had increased and highly-proliferative cord blood ECFCs.

KEYWORDS:

BPD; Bronchopulmonary dysplasia; CDH; Congenital diaphragmatic hernia; ECFC; EPC; Endothelial colony-forming cell; Endothelial progenitor cell; MNC; Mononuclear cells

PMID:
23684109
PMCID:
PMC3755084
DOI:
10.1016/j.jpeds.2013.04.010
[Indexed for MEDLINE]
Free PMC Article

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