Phytochemistry. 2013 Sep;93:199-202. doi: 10.1016/j.phytochem.2013.03.018. Epub 2013 May 1.

Cryptosporioptide: a bioactive polyketide produced by an endophytic fungus Cryptosporiopsis sp.

Saleem M¹, Tousif MI, Riaz N, Ahmed I, Schulz B, Ashraf M, Nasar R, Pescitelli G, Hussain H, Jabbar A, Shafiq N, Krohn K.

Author information

1: Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan. drsaleem_kr@yahoo.com

Abstract

An antibiotic polyketide, Cryptosporioptide (1) was isolated from the culture extract of the endophytic fungus Cryptosporiopsis sp. The structure of Cryptosporioptide has been established with the help of 1D ((1)H, (13)C), 2D NMR (HSQC, HMBC, COSY, NOESY) techniques and mass spectrometry (FABMS, HRFABMS). The absolute configuration was established by means of electronic circular dichroism (ECD). Cryptosporioptide exhibited both lipoxygenase inhibitory and anti-Bacillus megaterium activities.