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Pract Neurol. 2013 Jun;13(3):153-64. doi: 10.1136/practneurol-2013-000557. Epub 2013 Apr 24.

Mimics and chameleons in motor neurone disease.

Author information

1
University of Oxford Nuffield Department of Clinical Neurosciences, Oxford, UK. martin.turner@ndcn.ox.ac.uk

Abstract

The progression of motor neurone disease (MND) is currently irreversible, and the grave implications of diagnosis naturally fuels concern among neurologists over missing a potential mimic disorder. There is no diagnostic test for MND but in reality there are few plausible mimics in routine clinical practice. In the presence of a progressive pure motor disorder, signs such as florid fasciculations, bilateral tongue wasting, the 'split hand', head drop, emotionality, and cognitive or behavioural impairment carry high positive predictive value. MND is clinically heterogeneous, however, with some important chameleon-like presentations and considerable variation in clinical course. Lack of confidence about the scope of such variation, or an approach to diagnosis emphasising investigations over clinical common sense, has the potential to exacerbate diagnostic delay in MND and impede timely planning of the care which is essential to maximising quality of life.

KEYWORDS:

MOTOR NEURON DISEASE

PMID:
23616620
PMCID:
PMC3664389
DOI:
10.1136/practneurol-2013-000557
[Indexed for MEDLINE]
Free PMC Article

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