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Front Genet. 2013 Mar 6;4:25. doi: 10.3389/fgene.2013.00025. eCollection 2013.

A novel classification system for evolutionary aging theories.

Author information

1
Heddle Initiative Research Unit, Advanced Science Institute Wako, Saitama, Japan ; Department of Investigative Pathology, Graduate School of Biomedical Sciences, Nagasaki University Nagasaki, Japan ; Department of Biological Sciences, Tokyo Metropolitan University Hachioji, Tokyo, Japan.

Abstract

Theories of lifespan evolution are a source of confusion amongst aging researchers. After a century of aging research the dispute over whether the aging process is active or passive persists and a comprehensive and universally accepted theoretical model remains elusive. Evolutionary aging theories primarily dispute whether the aging process is exclusively adapted to favor the kin or exclusively non-adapted to favor the individual. Interestingly, contradictory data and theories supporting both exclusively programmed and exclusively non-programmed theories continue to grow. However, this is a false dichotomy; natural selection favors traits resulting in efficient reproduction whether they benefit the individual or the kin. Thus, to understand the evolution of aging, first we must understand the environment-dependent balance between the advantages and disadvantages of extended lifespan in the process of spreading genes. As described by distinct theories, different niches and environmental conditions confer on extended lifespan a range of fitness values varying from highly beneficial to highly detrimental. Here, we considered the range of fitness values for extended lifespan and develop a fitness-based framework for categorizing existing theories. We show that all theories can be classified into four basic types: secondary (beneficial), maladaptive (neutral), assisted death (detrimental), and senemorphic aging (varying between beneficial to detrimental). We anticipate that this classification system will assist with understanding and interpreting aging/death by providing a way of considering theories as members of one of these classes rather than consideration of their individual details.

KEYWORDS:

altruism; caloric restriction; evolution; longevity; senemorphism; senescence

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