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Eye (Lond). 2013 Apr;27(4):507-14. doi: 10.1038/eye.2013.4. Epub 2013 Feb 22.

Use of Fourier-domain OCT to detect retinal nerve fiber layer degeneration in Parkinson's disease patients.

Author information

1
Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain.

Abstract

PURPOSE:

To demonstrate axonal loss in the retinal nerve fiber layer (RNFL) of patients with Parkinson's disease (PD) and to evaluate the ability of Fourier-domain optical coherence tomography (OCT) to detect RNFL degeneration and retinal thinning in these patients.

METHODS:

PD patients (n=100) and healthy subjects (n=100) were included in the study and underwent visual acuity, color vision, and OCT examinations using two next-generation Fourier-domain devices (Spectralis and Cirrus). Differences in the RNFL thicknesses were compared between patients and controls.

RESULTS:

RNFL thicknesses were significantly reduced in PD patients compared with healthy subjects, especially those obtained using the Spectralis OCT, in the inferotemporal quadrant (155.6±16.5 μm in healthy eyes vs 142.1±24.9 μm in patients, P=0.040) and in the superotemporal quadrant (142.6±20.9 μm in healthy eyes vs 132.77±18.6 μm in PD patients, P=0.046). Significant differences were observed between controls and patients in relation to mean macular thickness (P=0.031), foveal thickness (P=0.030), and inferior outer thickness (P=0.019).

CONCLUSION:

PD is associated with RNFL loss and retinal thinning, which is detectable by Fourier-domain OCT measurements.

PMID:
23429414
PMCID:
PMC3626016
DOI:
10.1038/eye.2013.4
[Indexed for MEDLINE]
Free PMC Article

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