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J Leukoc Biol. 2013 Oct;94(4):671-5. doi: 10.1189/jlb.1012540. Epub 2012 Dec 18.

Crosstalk between neutrophils and dendritic cells: a context-dependent process.

Author information

1
1.WHO Immunology Research and Training Center, University of Lausanne, Boveresses 155, 1066 Epalinges, Switzerland. fabienne.tacchini-cottier@unil.ch.

Abstract

Neutrophils are massively and rapidly recruited following infection. They migrate to the site of acute infection and also transiently to dLNs. In addition to their well-established role as microbial killers, accumulating evidence shows that neutrophils can play an immunoregulatory role. Neutrophils were recently shown to influence the activation of different leukocyte types including NK cells, B cells, and DCs. DCs are professional APCs playing a key role to the launching and regulation of the immune response; thus, crosstalk between neutrophils and resident or newly recruited DCs may have a direct impact on the development of the antigen-specific immune response and thereby, on the outcome of infection. Neutrophils may regulate DC recruitment and/or activation. We will review here recent progress in the field, including those presented during the first international symposium on "Neutrophil in Immunity", held in Qu├ębec, Canada, in June 2012, and discuss how neutrophil regulatory action on DCs may differ depending on the type of invading microorganism and local host factors.

KEYWORDS:

BCG; Leishmania; alarmins; cDC; chemokines; pDC

PMID:
23250891
DOI:
10.1189/jlb.1012540
[Indexed for MEDLINE]

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