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Curr Opin Pharmacol. 2012 Oct;12(5):615-22. doi: 10.1016/j.coph.2012.08.001. Epub 2012 Aug 21.

Monoclonal antibody therapeutics: history and future.

Author information

1
Biologics Safety Assessment, MedImmune, Granta Park, Cambridge CB21 6GH, UK. bussn@medimmune.com

Abstract

Over the last three decades, monoclonal antibodies have made a dramatic transformation from scientific tools to powerful human therapeutics. At present, approximately 30 therapeutic monoclonal antibodies are marketed in the United States and Europe in a variety of indications, with sales in the US alone reaching approximately $18.5 billion in 2010. This review describes how antibody engineering has revolutionized drug discovery and what are considered the key areas for future development in the monoclonal antibody therapy field.

PMID:
22920732
DOI:
10.1016/j.coph.2012.08.001
[Indexed for MEDLINE]

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