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Addiction. 2012 Jul;107(7):1349-53. doi: 10.1111/j.1360-0443.2012.03801.x. Epub 2012 Mar 22.

Continuing to wear nicotine patches after smoking lapses promotes recovery of abstinence.

Author information

1
School of Pharmacy and Menzies Research Institute Tasmania, University of Tasmania, Hobart, TAS, Australia.

Abstract

AIMS:

  Smokers who lapse during a cessation attempt are at particularly high risk of relapse, so interventions to help smokers recover from lapses are urgently needed. Two recent studies have suggested continuing to use nicotine patches following a lapse may be a beneficial relapse prevention strategy. However, to date no study that uses approved doses of nicotine patches under real-world conditions has tested this hypothesis.

DESIGN AND SETTING:

  Clinical trial conducted across eight US study sites.

PARTICIPANTS AND MEASUREMENTS:

  Using data from 509 subjects (240 active; 269 placebo) who lapsed during weeks 3-5 of treatment in a randomized, double-blind placebo-controlled trial of 21-mg nicotine patches, we examined whether active nicotine patch use improved the chances of recovering abstinence (7-day point-prevalence) at weeks 6 and 10.

FINDINGS:

  Active patch use (versus placebo) increased the likelihood of recovery from a lapse both at 6 weeks [8.3% versus 0.8%; relative risk (RR) = 11.0, P < 0.001] and at 10 weeks (9.6% versus 2.6%; RR = 3.7, P < 0.001).

CONCLUSIONS:

  Continuing treatment to aid smoking cessation with active patches promotes recovery from lapses. Smokers should be encouraged to persist with patch treatment if they lapse to smoking.

[Indexed for MEDLINE]

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