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Nat Med. 2011 Nov 7;17(11):1402-9. doi: 10.1038/nm.2541.

Under pressure: the search for the essential mechanisms of hypertension.

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Division of Nephrology, Department of Medicine, Cardiovascular Research Center, Duke University, Durham, North Carolina, USA.


High blood pressure, or hypertension, is a very common disorder with a substantial impact on public health because of its associated complications. Despite the high prevalence of essential hypertension and years of research, the basic causes remain obscure. Here I review recent advances in understanding the pathophysiology of hypertension. I present a general overview of the field and, by necessity, use broad strokes to portray recent progress and place it in context. For this purpose, I use illustrative examples from the large number of important developments in hypertension research over the last five years. The intent of this review is to provide a sense of where the field is progressing, with an emphasis on work that sheds light on pathogenic mechanisms and that is therefore likely to inform new translational advances.

[Indexed for MEDLINE]

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