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Philos Trans A Math Phys Eng Sci. 2011 Oct 13;369(1952):3840-54. doi: 10.1098/rsta.2011.0120.

Quantitative modelling of sleep dynamics.

Author information

1
School of Physics, University of Sydney, Sydney, NSW 2006, Australia. p.robinson@physics.usyd.edu.au

Abstract

Arousal is largely controlled by the ascending arousal system of the hypothalamus and brainstem, which projects to the corticothalamic system responsible for electroencephalographic (EEG) signatures of sleep. Quantitative physiologically based modelling of brainstem dynamics theory is described here, using realistic parameters, and links to EEG are outlined. Verification against a wide range of experimental data is described, including arousal dynamics under normal conditions, sleep deprivation, stimuli, stimulants and jetlag, plus key features of wake and sleep EEGs.

PMID:
21893531
DOI:
10.1098/rsta.2011.0120
[Indexed for MEDLINE]

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