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Nanotechnology. 2008 Jan 9;19(1):015101. doi: 10.1088/0957-4484/19/01/015101. Epub 2007 Nov 29.

Carbon nanopipettes for cell probes and intracellular injection.

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Department of Mechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104, USA.


We developed integrated, carbon-based pipettes with nanoscale dimensions (CNP) that can probe cells with minimal intrusion, inject fluids into the cells, and concurrently carry out electrical measurements. Our manufacturing technique does not require cumbersome nanoassembly and is amenable to mass production. Using CNPs, we demonstrate the injection of reagents into cells with minimal intrusion and without inhibiting cell growth.

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