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Int J Biochem Cell Biol. 2011 Aug;43(8):1090-103. doi: 10.1016/j.biocel.2011.04.001. Epub 2011 Apr 8.

Intrinsically disordered proteins from A to Z.

Author information

1
Department of Molecular Medicine, University of South Florida, FL 33612, USA. vuversky@health.usf.edu

Abstract

The ideas that proteins might possess specific functions without being uniquely folded into rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of any given proteome would have been considered as a preposterous fiction 15 or even 10 years ago. The situation has changed recently, and the existence of functional yet intrinsically disordered proteins and regions has become accepted by a significant number of protein scientists. These fuzzy objects with fuzzy structures and fuzzy functions are among the most interesting and attractive targets for modern protein research. This review summarizes some of the major discoveries and breakthroughs in the field of intrinsic disorder by representing related concepts and definitions.

PMID:
21501695
DOI:
10.1016/j.biocel.2011.04.001
[Indexed for MEDLINE]

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