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Biochim Biophys Acta. 2011 Nov;1813(11):1965-70. doi: 10.1016/j.bbamcr.2011.03.013. Epub 2011 Apr 1.

Interplay between FOXO, TOR, and Akt.

Author information

1
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, IL 60607, USA. nhay@uic.edu

Abstract

FOXO transcription factors have emerged as rheostats that coordinate the activities of Akt and targets of rapamycin complexes (TORCs). This review summarizes the regulatory circuits mediated by the activation of FOXO, which in turn modulate Akt and TORCs activities. The biological significance of these regulatory circuits is discussed in this article. This article is part of a Special Issue entitled: P13K-AKT-FoxO axis in cancer and aging.

PMID:
21440577
PMCID:
PMC3427795
DOI:
10.1016/j.bbamcr.2011.03.013
[Indexed for MEDLINE]
Free PMC Article

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