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Antiviral Res. 2011 Apr;90(1):64-9. doi: 10.1016/j.antiviral.2011.02.008. Epub 2011 Feb 26.

Emodin inhibits current through SARS-associated coronavirus 3a protein.

Author information

1
Shanghai Research Center for Acupuncture & Meridians, 199 Guoshoujing Rd., Shanghai 201203, China.

Abstract

The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and would be a source for the development of novel therapeutic agents. Here we demonstrate that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as virus release from HCoV-OC43 with a K1/2 value of about 20 μM. We suggest that viral ion channels, in general, may be a good target for the development of antiviral agents.

PMID:
21356245
PMCID:
PMC7114100
DOI:
10.1016/j.antiviral.2011.02.008
[Indexed for MEDLINE]
Free PMC Article

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