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J Am Chem Soc. 2011 Mar 2;133(8):2338-41. doi: 10.1021/ja109044r. Epub 2010 Nov 29.

Production of lantipeptides in Escherichia coli.

Author information

1
Howard Hughes Medical Institute, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Abstract

Lantipeptides are ribosomally synthesized and posttranslationally modified peptides containing thioether cross-links. We describe the preparation of seven different lantipeptides in Escherichia coli and demonstrate that this methodology can be used to incorporate nonproteinogenic amino acids.

PMID:
21114289
PMCID:
PMC3044485
DOI:
10.1021/ja109044r
[Indexed for MEDLINE]
Free PMC Article

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