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Metallomics. 2010 Jun;2(6):378-92. doi: 10.1039/b926659c. Epub 2010 May 13.

Metalloproteomics and metal toxicology of α-synuclein.

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Molecular Kinetics Inc., 6201 La Pas Trail, Indianapolis, IN 46268, USA.


Significant evidence has been accumulated linking exposure to heavy metals and/or distortion of metal homeostasis with the development of various neurodegenerative diseases. α-Synuclein is known to be involved in pathogenesis of a subset of neurodegenerative diseases collectively known as synucleinopathies. Therefore the interplay between metals, α-synuclein and neurodegeneration has attracted significant attention of researchers. This review discusses some of the aspects of the α-synuclein metalloproteomics and represents the peculiarities and consequences of α-synuclein interaction with various metal ions. Both non-specific and specific binding of this protein to metals is considered together with the analysis of the effects of such interactions on α-synuclein structure and aggregation propensity.

[Indexed for MEDLINE]

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