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Exerc Sport Sci Rev. 2010 Jul;38(3):114-21. doi: 10.1097/JES.0b013e3181e3728f.

Nonhomeostatic control of human appetite and physical activity in regulation of energy balance.

Author information

1
School of Kinesiology, The University of Michigan, Ann Arbor, MI 48109, USA. Katarina@umich.edu

Abstract

Ghrelin and leptin, putative controllers of human appetite, have no effect on human meal-to-meal appetite but respond to variations in energy availability. Nonhomeostatic characteristics of appetite and spontaneous activity stem from inhibition by leptin and ghrelin of brain reward circuit that is responsive to energy deficit, but refractory in obesity, and from the operation of a meal-timing circadian clock.

PMID:
20577059
PMCID:
PMC2943207
DOI:
10.1097/JES.0b013e3181e3728f
[Indexed for MEDLINE]
Free PMC Article

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