Format

Send to

Choose Destination
Acta Paediatr. 2010 May;99(5):770-773. doi: 10.1111/j.1651-2227.2010.01701.x. Epub 2010 Mar 1.

Hormonal alterations in adolescent chronic fatigue syndrome.

Author information

1
.Division of Paediatrics, Oslo University Hospital, Oslo, Norway.Department of Endocrinology, Oslo University Hospital, Oslo, Norway.

Abstract

AIM:

The chronic fatigue syndrome is associated with alterations in the hypothalamus-pituitary-adrenal axis and cardiovascular autonomic nervous activity, suggesting a central dysregulation. This study explored differences among adolescent chronic fatigue syndrome patients and healthy controls regarding antidiuretic hormone, the renin-angiotensin-aldosterone-system, sex hormones and cardiac peptides.

METHODS:

We included a consecutive sample of 67 adolescents aged 12-18 years with chronic fatigue syndrome diagnosed according to a thorough and standardized set of investigations, and a volunteer sample of 55 healthy control subjects of equal gender and age distribution. Hormones were assayed with standard laboratory methods.

RESULTS:

Among patients, plasma antidiuretic hormone was significantly decreased and serum osmolality and plasma renin activity were significantly increased (p < or = 0.001). Serum concentration of aldosterone, cortisol, NT-proBNP and sex hormones were not significantly different in the two groups.

CONCLUSION:

Chronic fatigue syndrome in adolescents is associated with alterations in hormonal systems controlling osmolality and blood volume, possibly supporting a theory of central dysregulation.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center