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Stereotact Funct Neurosurg. 2010;88(1):56-63. doi: 10.1159/000268743. Epub 2009 Dec 24.

Safety and function of a new clinical intracerebral microinjection instrument for stem cells and therapeutics examined in the Göttingen minipig.

Author information

1
Department of Neurobiology, Institute of Anatomy, University of Aarhus, Aarhus, Denmark.

Abstract

BACKGROUND:

A new intracerebral microinjection instrument (IMI) allowing multiple electrophysiologically guided microvolume injections from a single proximal injection path in rats has been adapted to clinical use by coupling the IMI to an FHC microTargeting Manual Drive, designed to be used with standard stereotactic frame-based systems and FHC frameless microTargeting Platforms.

METHODS:

The function and safety of the device was tested by conducting bilateral electrophysiologically guided microinjections of fluorescent microspheres in the substantia nigra of 4 Göttingen minipigs.

RESULTS:

The device was easy to handle and enabled accurate electrophysiologically guided targeting of the substantia nigra with minimal local tissue damage.

CONCLUSION:

The IMI is suitable for clinical use and may prove useful for various stereotactic procedures that require high levels of precision and/or three-dimensional distribution of therapeutics within the brain.

PMID:
20051711
DOI:
10.1159/000268743
[Indexed for MEDLINE]

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