Format

Send to

Choose Destination
Biotechnol J. 2009 Dec;4(12):1653-70. doi: 10.1002/biot.200900234.

Accomplishments in genome-scale in silico modeling for industrial and medical biotechnology.

Author information

1
Institute for Genomic Biology, University of Illinois, Urbana, IL, USA.

Abstract

Driven by advancements in high-throughput biological technologies and the growing number of sequenced genomes, the construction of in silico models at the genome scale has provided powerful tools to investigate a vast array of biological systems and applications. Here, we review comprehensively the uses of such models in industrial and medical biotechnology, including biofuel generation, food production, and drug development. While the use of in silico models is still in its early stages for delivering to industry, significant initial successes have been achieved. For the cases presented here, genome-scale models predict engineering strategies to enhance properties of interest in an organism or to inhibit harmful mechanisms of pathogens. Going forward, genome-scale in silico models promise to extend their application and analysis scope to become a trans-formative tool in biotechnology.

PMID:
19946878
PMCID:
PMC3160784
DOI:
10.1002/biot.200900234
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center