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Curr Opin Neurobiol. 2009 Dec;19(6):621-8. doi: 10.1016/j.conb.2009.10.003. Epub 2009 Nov 5.

Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection.

Author information

1
Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.

Abstract

The striatum is thought to play a central role in learning how to choose acts that lead to reward and avoid punishment. Dopamine-dependent modification of striatal synapses in the action selection circuitry has long been thought to be a key step toward this type of learning. The development of new genetic and optical tools has pushed this field forward in the last couple of years, demanding a re-evaluation of models of how experience controls dopamine-dependent synaptic plasticity and how disease states like Parkinson's disease affect the striatal circuitry.

PMID:
19896832
PMCID:
PMC2818437
DOI:
10.1016/j.conb.2009.10.003
[Indexed for MEDLINE]
Free PMC Article

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