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IEEE Signal Process Lett. 2008 Jan 1;15:413-416.

A Parallel Independent Component Analysis Approach to Investigate Genomic Influence on Brain Function.

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J. Liu and V. D. Calhoun are with the MIND Institute and the Department of Electrical Computer Engineering, University of New Mexico, Albuquerque, NM 87131 USA (e-mail: ; ).


Relationships between genomic data and functional brain images are of great interest but require new analysis approaches to integrate the high-dimensional data types. This letter presents an extension of a technique called parallel independent component analysis (paraICA), which enables the joint analysis of multiple modalities including interconnections between them. We extend our earlier work by allowing for multiple interconnections and by providing important overfitting controls. Performance was assessed by simulations under different conditions, and indicated reliable results can be extracted by properly balancing overfitting and underfitting. An application to functional magnetic resonance images and single nucleotide polymorphism array produced interesting findings.

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