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Cancer Lett. 2010 Mar 28;289(2):140-50. doi: 10.1016/j.canlet.2009.07.004. Epub 2009 Aug 3.

Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.

Author information

1
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Abstract

Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the gamma-herpesvirinae subfamily. KSHV has been associated with the development of three neoplastic diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). In this review, we discuss the three KSHV-associated malignancies, KSHV genome, latent and lytic aspects of the viral lifecycle, putative viral oncogenes, as well as therapeutic regimens used for the treatment of KS, PEL, and MCD.

PMID:
19651473
PMCID:
PMC4342847
DOI:
10.1016/j.canlet.2009.07.004
[Indexed for MEDLINE]
Free PMC Article

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