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Gen Comp Endocrinol. 2009 Sep 1;163(1-2):70-6. doi: 10.1016/j.ygcen.2009.03.008. Epub 2009 Mar 24.

Stress and immunity in wild vertebrates: timing is everything.

Author information

1
University of South Florida, Department of Integrative Biology, Tampa, FL 33620, USA. lmartin@cas.usf.edu

Abstract

Stress has profound effects on vertebrate immunity, but most studies have considered stress-immune interactions in terms of wild animals enduring demanding, but predictable activities (e.g., immune alterations during breeding). A growing biomedical literature, however, indicates that stress may not be obligatorily immunosuppressive; in response to transient, unpredictable stressors, immune activity can be enhanced, especially in body areas requiring immune protection. Also, immune sensitivity to stressors is not fixed throughout life; oftentimes, glucocorticoid (GC) insensitivity can be induced. Further GC sensitivity can be programmed early in life; greater exposure to stressors prior to maturity heightens GC effects on immunity in adulthood. In the present paper, I review the cellular and molecular mechanisms that link stress responses to immune adjustments over short time scales in domesticated species then I attempt to place stress-immune interactions in a naturalistic, organismal context. When, how and why stressors affect immunity in wild animals remains practically unstudied.

PMID:
19318107
DOI:
10.1016/j.ygcen.2009.03.008
[Indexed for MEDLINE]

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