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Nat Rev Neurosci. 2009 Mar;10(3):235-41. doi: 10.1038/nrn2591.

The bright side of the glial scar in CNS repair.

Author information

1
Asya Rolls, Ravid Shechter and Michal Schwartz are at the Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel.

Abstract

Following CNS injury, in an apparently counterintuitive response, scar tissue formation inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar-modulating treatments have become a leading therapeutic goal in the field of spinal cord injury. However, increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process. How can these opposing effects be reconciled? Perhaps it is all a matter of timing.

PMID:
19229242
DOI:
10.1038/nrn2591
[Indexed for MEDLINE]

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