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Bioorg Med Chem Lett. 2008 Sep 1;18(17):4872-5. doi: 10.1016/j.bmcl.2008.07.071. Epub 2008 Jul 24.

Physiochemical drug properties associated with in vivo toxicological outcomes.

Author information

1
Pfizer Research Technology Center, Cambridge, MA 02139, USA.

Abstract

Relationships between physicochemical drug properties and toxicity were inferred from a data set consisting of animal in vivo toleration (IVT) studies on 245 preclinical Pfizer compounds; an increased likelihood of toxic events was found for less polar, more lipophilic compounds. This trend held across a wide range of types of toxicity and across a broad swath of chemical space.

PMID:
18691886
DOI:
10.1016/j.bmcl.2008.07.071
[Indexed for MEDLINE]

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