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Nat Rev Immunol. 2008 Jul;8(7):512-22. doi: 10.1038/nri2318.

Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.

Author information

1
Department of Immunobiology and the Arizona Center on Aging, University of Arizona, Tucson, Arizona 85724, USA. nikolich@e-mail.arizona.edu

Abstract

A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious defence against infection with new or re-emerging pathogens throughout life. In the last third of the mammalian lifespan, the maintenance of a balanced T-cell repertoire becomes highly challenging because of the changes in T-cell production and consumption. In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency.

PMID:
18469829
PMCID:
PMC5573867
DOI:
10.1038/nri2318
[Indexed for MEDLINE]
Free PMC Article

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