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Ecotoxicol Environ Saf. 2008 May;70(1):47-52. doi: 10.1016/j.ecoenv.2007.07.003. Epub 2008 Jan 22.

Acute and chronic effects of ibuprofen in the mollusc Planorbis carinatus (Gastropoda: Planorbidae).

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AstraZeneca Global Safety, Health and Environment, Brixham Environmental Laboratory, Devon TQ5 8BA, UK.


Laboratory populations of freshwater Keeled rams horn snails (Planorbis carinatus Muller, 1774) were exposed as adults to measured concentrations of ibuprofen free base (CAS number 15687-27-1) for up to 21 d using methanol (0.1 mL/L) as a carrier solvent. Under flow-through conditions, the 48 and 72 h LC50 values were both 17.1mg/L (95% confidence intervals 5.9-72.3mg/L), while 21 d LOEC and NOEC values based on survival were >5.36 and 5.36 mg/L, respectively. Reproduction (in terms of hatching success) 21d LOEC and NOEC values were 5.36 and 2.43 mg/L, respectively. Growth (wet weight) was the most sensitive endpoint measured at 21 d, with LOEC and NOEC values of 2.43 and 1.02 mg/L, respectively. We found P. carinatus to be amenable to laboratory culture and this preliminary study suggests that this species may have further potential as a useful molluscan model in ecotoxicology.

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