Format

Send to

Choose Destination
Schizophr Res. 2008 Jan;98(1-3):157-62. Epub 2007 Nov 26.

Diffusion tensor imaging in schizophrenia: relationship to symptoms.

Author information

1
Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA. lskelly@harthosp.org

Abstract

In this diffusion tensor imaging (DTI) study, the authors investigated white matter integrity in schizophrenia and the relationships between white matter alterations and specific symptoms of the disorder. We compared DTI images of 25 schizophrenia patients and 25 matched healthy controls and performed voxel-wise correlational analyses using the patient's DTI data and their severity scores of positive and negative symptoms. We found diffuse deficits in multiple types of white matter tracts in schizophrenia, and an inverse relationship of DTI fractional anisotropy (FA) values with positive symptom scores in association fibers, supporting a "disconnection" hypothesis of positive symptoms in schizophrenia.

PMID:
18031994
PMCID:
PMC2668961
DOI:
10.1016/j.schres.2007.10.009
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Grant support

Publication types

MeSH terms

Grant support

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center