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J Craniofac Surg. 2007 Sep;18(5):1068-70.

Ozone therapy in extractive surgery on patients treated with bisphosphonates.

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Department of Maxillo-Facial Surgery, University of Rome La Sapienza, Policlinico Umberto I, Rome, Italy.


It is certain that oral extractive surgery is a remarkable trigger to avascular osteonecrosis of the jaw in patients treated with pyrophosphate analogous. This acquisition limits the use of endo-oral surgery in those patients, even when they have already developed the lesions. In this study, we present the results obtained in a group of 15 patients deriving from a 33-patient cluster with osteonecrosis of the jaw in treatment at our department with a new protocol based on ozone therapy. The object of this article is to demonstrate how dental extraction becomes possible in a patient with avascular bisphosphonate-related jaw osteonecrosis or in those who simply received pyrophosphate analogous when proper treatment with ozone therapy has been done.

[Indexed for MEDLINE]

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