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Brain Behav Immun. 2008 Feb;22(2):129-39. Epub 2007 Oct 29.

Human psychoneuroimmunology: 20 years of discovery.

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Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, University of California, 300 Medical Plaza, Suite 3-109, Los Angeles, CA 90095-7057, USA.


An important component of psychoneuroimmunology research is to reveal the myriad ways that behaviors and health are inter-related, with a focus on the immunological mechanisms that underlie these interactions. Research in human psychoneuroimmunology has shown that immunoregulatory processes are an integral part of a complex network of adaptive responses. As such, this review provides a perspective from our laboratory over the last 20 years to define the inter-relationships between behavior and immunity; to identify the hypothalamic pituitary adrenal (HPA) and autonomic mechanisms that link the central nervous system and immune responses; to examine the clinical implications of immune alterations during depression or life stress on inflammatory and infectious disease risk; and to explore the reciprocal role of immune mediators on behavior in humans.

[Indexed for MEDLINE]

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