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Kidney Int. 2007 Oct;72(7):781-2.

Hypertension in connexin40-null mice: a renin disorder.

Author information

1
Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA. spray@aecom.yu.edu

Abstract

Studies described in this issue indicate that the gap junction protein connexin40 (Cx40) appears to play an unexpected role in blood pressure regulation. In mice lacking this gap junction protein, renin secretion is high and not regulated by arteriolar pressure.

PMID:
17882239
DOI:
10.1038/sj.ki.5002515
[Indexed for MEDLINE]
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