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Bioorg Med Chem Lett. 2007 Oct 1;17(19):5336-9. Epub 2007 Aug 15.

Carbocyclic 3'-deoxyadenosine-based highly potent bisubstrate-analog inhibitor of basophilic protein kinases.

Author information

1
Institute of Organic and Bioorganic Chemistry, University of Tartu, 2 Jakobi Street, 51014 Tartu, Estonia.

Abstract

Carbocyclic analogs of 3'-deoxyadenosine were synthesized as racemates and the resulting stereoisomers were separated by chromatography on a chiral column. The conjugation of obtained compounds with hexa-(D-arginine) via 6-aminohexanoic acid linker led to a highly potent inhibitor of several basophilic protein kinases with some selectivity towards cAMP-dependent protein kinase.

PMID:
17716894
DOI:
10.1016/j.bmcl.2007.08.016
[Indexed for MEDLINE]

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