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Nature. 2007 Aug 23;448(7156):883-8.

Integrating molecular and network biology to decode endocytosis.

Author information

1
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

Abstract

The strength of network biology lies in its ability to derive cell biological information without a priori mechanistic or molecular knowledge. It is shown here how a careful understanding of a given biological pathway can refine an interactome approach. This permits the elucidation of additional design principles and of spatio-temporal dynamics behind pathways, and aids in experimental design and interpretation.

PMID:
17713526
DOI:
10.1038/nature06031
[Indexed for MEDLINE]

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