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Bioinformatics. 2007 Sep 15;23(18):2491-2. Epub 2007 Aug 20.

Con-Struct Map: a comparative contact map analysis tool.

Author information

1
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Abstract

Con-Struct Map is a graphical tool for the comparative study of protein structures. The tool detects potential conserved residue contacts shared by multiple protein structures by superimposing their contact maps according to a multiple structure alignment. In general, Con-Struct Map allows the study of structural changes resulting from, e.g. sequence substitutions, or alternatively, the study of conserved components of a structure framework across structurally aligned proteins. Specific applications include the study of sequence-structure relationship in distantly related proteins and the comparisons of wild type and mutant proteins.

AVAILABILITY:

http://pdbrs3.sdsc.edu/ConStructMap/viewer_argument_generator/singleArguments.

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

PMID:
17709340
DOI:
10.1093/bioinformatics/btm356
[Indexed for MEDLINE]

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