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J Virol. 2007 Oct;81(19):10818-21. Epub 2007 Jul 25.

The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses.

Author information

1
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. tft9@cdc.gov

Abstract

Mice carrying a wild-type Mx1 gene (Mx1+/+) differ from standard laboratory mice (Mx1-/-) in being highly resistant to infection with common laboratory strains of influenza A virus. We report that Mx1 also protects mice against the pandemic human 1918 influenza virus and a highly lethal human H5N1 strain from Vietnam. Resistance to H5N1 of Mx1+/+ but not Mx1-/- mice was enhanced if the animals were treated with a single dose of exogenous alpha interferon before infection. Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses.

PMID:
17652381
PMCID:
PMC2045488
DOI:
10.1128/JVI.01116-07
[Indexed for MEDLINE]
Free PMC Article

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