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AIDS. 2007 Jul 31;21(12):1503-6.

A new approach for 'deep salvage' trials in advanced HIV infection.

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Center for AIDS Research, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA.


One of the most difficult problems in HIV care today is the management of individuals infected with multidrug-resistant viruses. Well-controlled, carefully designed clinical trials have recently resulted in the approval of several new antiviral agents for the treatment of drug-resistant HIV. The design of these trials has come at the cost of the predictable emergence of drug-resistant viruses among individuals randomly assigned to receive a suboptimal revised treatment regimen. We propose here a different approach to the evaluation of drug efficacy in individuals harbouring multidrug-resistant HIV.

[Indexed for MEDLINE]

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